SF Isaac Guerendo
NFL player. Position: RB. Team: SF.
Quick Facts
- Position: Running Back
- Team: SF (San Francisco 49ers)
- Age: 25
- Bye week (2026): 10
- FantasyPros PPR rank (2026): TBD
- Draft: 2024 (4th round)
2026 Outlook
Guerendo showed promise as a 2024 rookie (430 rushing yards on 84 carries, 4 TDs) but regressed dramatically in Year 2, seeing zero offensive snaps after the 49ers acquired Brian Robinson. He's competing for depth snaps behind Christian McCaffrey but suffered a torn pectoral muscle lifting weights in late May, sidelining him until late in training camp. The injury derails any momentum he might've gained in a rebuild year. (per Nick Bosa says he is on track for training camp and Week 1 with the 49ers)
Roster competition from 2026 draft: The 49ers selected Kaelon Black (RB, Round 3, #90 overall) in 2026, a reach-grade pick that could pose direct competition for Guerendo's roster spot. Black's best path is to push Guerendo off the 53-man roster, though draft critics view Black as the worst pick in San Francisco's class (per 49ers' best, worst and most surprising picks from their 2026 NFL Draft class)
Aug 28 roster solution — PUP placement: Rather than cutting Guerendo outright, the 49ers placed him on injured reserve with a PUP designation ahead of the 53-man roster deadline. This move preserves his spot while reducing offensive roster pressure and allowing continued recovery. Due to a new NFL rule, Guerendo can resume practicing in Week 3 (eligible to return to game action in Week 5), creating a clear pathway back to action without forcing a premature decision. The 49ers' decision to keep Guerendo on this timeline suggests they view his talent as worth preserving rather than risking him to waivers. (per 49ers 53-man roster projection: Where position battles stand ahead of cutdown day - The San Francisco Standard).
Role / Depth Chart
Third-team RB behind Christian McCaffrey and Brian Robinson.
Injury Status
Torn pectoral muscle (sustained May 2026, lifting weights). Placed on PUP list at 53-man roster deadline (Aug. 28). Due to a new NFL rule, Guerendo will be eligible to resume practice in Week 3 and return to game action in Week 5. This preserves his roster spot while providing extended recovery time without counting against the 53-man limit. (per 49ers 53-man roster projection: Where position battles stand ahead of cutdown day - The San Francisco Standard)
Recent News
- 2026-05-05 — RB Isaac Guerendo In Uphill Battle To Make 49ers’ Roster; Latest On Team’s LG... (RB Isaac Guerendo In Uphill Battle To Make 49ers’ Roster; Latest On Team’s LG...)
- 2026-05-30 — NFL Backfield Rankings: Grading Every Team's Running Backs [2026] (NFL Backfield Rankings: Grading Every Team's Running Backs [2026])
- 2026-04-26 — Evaluating 49ers’ 2026 draft class: No A’s, some eyebrow-raisers and one polarizing pick (Evaluating 49ers’ 2026 draft class: No A’s, some eyebrow-raisers and one polarizing pick)
- 2026-04-29 — 49ers post-NFL Draft depth chart: Where do rookies fit, and what holes remain? - The... (49ers post-NFL Draft depth chart: Where do rookies fit, and what holes remain? - The...)
- 2026-04-15 — Ryan Heath's 2026 Rookie RB Rankings (Ryan Heath's 2026 Rookie RB Rankings)
- 2026-05-18 — 6 Late-Round Dynasty Rookie Draft Targets (2026 Fantasy Football) (6 Late-Round Dynasty Rookie Draft Targets (2026 Fantasy Football))
- 2026-05-19 — 2026 NFL OTA News Tracker (2026 NFL OTA News Tracker)
- 2026-04-27 — 2026 Dynasty Rookie Sleepers: Mid-to-Late Round Gems (2026 Dynasty Rookie Sleepers: Mid-to-Late Round Gems)
- 2026-05-26 — Fantasy Football 2026 49ers deep dive: Player outlooks, players to target, avoid at... (Fantasy Football 2026 49ers deep dive: Player outlooks, players to target, avoid at...)
- 2026-02-28 — Dynasty Fantasy Football Free Agency Preview 2026: San Francisco 49ers (Dynasty Fantasy Football Free Agency Preview 2026: San Francisco 49ers)
Open Questions
- Will Guerendo's pectoral injury cost him chances to fight his way back onto the field in 2026, or can he make a preseason splash?